GORULE violations assigned by BHF-UCL

Contents

gorule-0000005 IEA, ISS, ISO, ISM, ISA, IBA, RCA annotations ae not allowed for direct annotations to to 'protein binding ; GO:0005515 or GO:0005488 binding''

gorule-0000008 No annotations should be made to uninformative high level terms

gorule-0000016 With/From: IC annotations require a With/From GO ID

gorule-0000020 Automatic repair of annotations to merged or obsoleted terms

gorule-0000046 The ‘with’ field (GAF column 8) must be the same as the gene product (GAF column 2) when annotating to ‘self-binding’ terms.

gorule-0000061 Allowed gene product to term relations (gp2term)

MESSAGES

gorule-0000005

IEA, ISS, ISO, ISM, ISA, IBA, RCA annotations ae not allowed for direct annotations to to 'protein binding ; GO:0005515 or GO:0005488 binding''

• total: 2

messages

• WARNING - Violates GO Rule:GORULE:0000005: IEA, ISS, ISO, ISM, ISA, IBA, RCA annotations ae not allowed for direct annotations to 'binding ; GO:0005488' or 'protein binding ; GO:0005515'--`MGI MGI:3613677 Shank1 enables GO:0005515 GO_REF:0000024 ISS UniProtKB:Q9WV48 F SH3 and multiple ankyrin repeat domains protein 1 protein taxon:10090 20131017 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000005: IEA, ISS, ISO, ISM, ISA, IBA, RCA annotations ae not allowed for direct annotations to 'binding ; GO:0005488' or 'protein binding ; GO:0005515'--`MGI MGI:1277959 Dlg4 enables GO:0005515 GO_REF:0000024 ISS UniProtKB:P31016 F Disks large homolog 4 protein taxon:10090 20131017 BHF-UCL `

gorule-0000008

No annotations should be made to uninformative high level terms

• total: 9

messages

• WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI MGI:1095400 Zfpm1 involved_in GO:0032091 PMID:18063754 IDA P Zinc finger protein ZFPM1 protein taxon:10090 20110810 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI MGI:88246 Anxa2 involved_in GO:1905597 PMID:22848640 IMP P Annexin A2 protein taxon:10090 20161031 BHF-UCL occurs_in(UBERON:0002107),part_of(GO:0001921),part_of(GO:0032804),part_of(GO:1905599),part_of(GO:1905597),part_of(GO:1905602) `
• WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI MGI:98310 Ski involved_in GO:0043388 GO_REF:0000024 ISS UniProtKB:P12755 P Ski oncogene protein taxon:10090 20110403 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI MGI:1346859 Mapk3 involved_in GO:2000657 PMID:20037141 IMP P Mitogen-activated protein kinase 3 protein taxon:10090 20110707 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI MGI:98419 Sri involved_in GO:2000678 PMID:22338092 IMP P Sorcin protein taxon:10090 20130128 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI MGI:2443732 Dna2 involved_in GO:0090304 PMID:23604072 IDA P DNA replication ATP-dependent helicase/nuclease DNA2 protein taxon:10090 20151223 BHF-UCL part_of(GO:1902990) `
• WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI MGI:1345675 Trib3 involved_in GO:0032092 PMID:16794074 IDA P Tribbles homolog 3 protein taxon:10090 20100430 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI MGI:1915756 Ctnnbip1 involved_in GO:0043392 PMID:11751639 IDA P Beta-catenin-interacting protein 1 protein taxon:10090 20100723 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI MGI:1314872 Hipk2 involved_in GO:0032092 PMID:16407227 IDA P Homeodomain-interacting protein kinase 2 protein taxon:10090 20111205 BHF-UCL `

gorule-0000016

With/From: IC annotations require a With/From GO ID

• total: 1

messages

• WARNING - Violates GO Rule:GORULE:0000016: All IC annotations should include a GO ID in the "With/From" column that is also different from the entry in the "GO ID" column--`MGI MGI:97362 Nos3 located_in GO:0005737 PMID:11732991 IC GO:0005737 C Nitric oxide synthase 3 protein taxon:10090 20180821 BHF-UCL part_of(CL:0000115),part_of(UBERON:0011742),existence_overlaps(GO:0003180) `

gorule-0000020

Automatic repair of annotations to merged or obsoleted terms

• total: 6

messages

• ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI MGI:1346086 Aplnr involved_in GO:0060183 PMID:23603510 IMP P Apelin receptor protein taxon:10090 20210204 BHF-UCL causally_upstream_of(GO:0031065) `
• ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI MGI:88276 Ctnnb1 enables GO:1990226 PMID:22723415 IPI UniProtKB:O15047 F Catenin beta-1 protein taxon:10090 20210113 BHF-UCL occurs_in(GO:0005634),occurs_in(CL:0002322),has_input(UniProtKB:E9PYH6),part_of(GO:0051571) `
• ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI MGI:88276 Ctnnb1 enables GO:0003713 PMID:22723415 IDA F Catenin beta-1 protein taxon:10090 20210113 BHF-UCL has_input(UniProtKB:O70372),occurs_in(CL:0002322),causally_upstream_of(GO:0051973) `
• ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI MGI:88276 Ctnnb1 involved_in GO:0045944 PMID:22723415 IMP P Catenin beta-1 protein taxon:10090 20210113 BHF-UCL has_input(UniProtKB:O70372),occurs_in(CL:0002322),causally_upstream_of(GO:0051973) `
• WARNING - Obsolete class:Violates GORULE:0000020, but was repaired--`MGI MGI:98262 Ccl5 involved_in GO:0031328 GO_REF:0000024 ISS UniProtKB:P13501 P C-C motif chemokine 5 protein taxon:10090 20110224 BHF-UCL `
• WARNING - Obsolete class:Violates GORULE:0000020, but was repaired--`MGI MGI:87866 Acadl involved_in GO:0044242 PMID:9861014 IMP P Long-chain specific acyl-CoA dehydrogenase, mitochondrial protein taxon:10090 20091117 BHF-UCL `

gorule-0000046

The ‘with’ field (GAF column 8) must be the same as the gene product (GAF column 2) when annotating to ‘self-binding’ terms.

• total: 24

messages

• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:1195972 Terf2 enables GO:0042803 PMID:9326950 IPI UniProtKB:O35144 F Telomeric repeat-binding factor 2 protein taxon:10090 20081216 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:99665 Syt3 enables GO:0042803 PMID:10531343 IDA F Synaptotagmin-3 protein taxon:10090 20110630 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:1201414 Cer1 enables GO:0042803 PMID:10748465 IDA F Cerberus protein taxon:10090 20120213 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:1270845 Cidea enables GO:0042803 PMID:17080483 IDA F Lipid transferase CIDEA protein taxon:10090 20071212 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:1277234 Tbx15 enables GO:0042803 PMID:17584735 IPI UniProtKB:O70306 F T-box transcription factor TBX15 protein taxon:10090 20191030 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:1339753 Csf1 enables GO:0042803 PMID:19017797 IPI UniProtKB:P07141 F Macrophage colony-stimulating factor 1 protein taxon:10090 20100311 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:1339758 Csf1r enables GO:0042803 PMID:19017797 IPI UniProtKB:P09581 F Macrophage colony-stimulating factor 1 receptor protein taxon:10090 20090115 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:97361 Nos2 enables GO:0042803 PMID:9271491 IDA F Nitric oxide synthase, inducible protein taxon:10090 20080725 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:98262 Ccl5 enables GO:0042803 GO_REF:0000024 ISS UniProtKB:P13501 F C-C motif chemokine 5 protein taxon:10090 20240316 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:104593 Xcl1 enables GO:0042803 GO_REF:0000024 ISS UniProtKB:P47992 F Lymphotactin protein taxon:10090 20110403 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:108050 Ext2 enables GO:0042803 PMID:10639137 IDA F Exostosin-2 protein taxon:10090 20080228 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:103580 Hand2 enables GO:0042803 PMID:11812799 IPI UniProtKB:Q61039 F Heart- and neural crest derivatives-expressed protein 2 protein taxon:10090 20090827 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:95392 Eng enables GO:0042803 PMID:8194490 IPI UniProtKB:Q63961 F Endoglin protein taxon:10090 20081107 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:103577 Hand1 enables GO:0042803 PMID:10924525 IPI UniProtKB:Q64279 F Heart- and neural crest derivatives-expressed protein 1 protein taxon:10090 20090826 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:2442682 Slc30a8 enables GO:0042803 PMID:19095428 IPI UniProtKB:Q8BGG0 F Proton-coupled zinc antiporter SLC30A8 protein taxon:10090 20100128 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:2149946 Gopc enables GO:0042803 PMID:11520064 IPI UniProtKB:Q8BH60 F Golgi-associated PDZ and coiled-coil motif-containing protein protein taxon:10090 20110330 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:2180781 Slc8b1 enables GO:0042803 PMID:20018762 IPI UniProtKB:Q925Q3 F Mitochondrial sodium/calcium exchanger protein protein taxon:10090 20140904 BHF-UCL occurs_in(UBERON:0000948)|occurs_in(UBERON:0000955) `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:1930704 Bhlhe41 enables GO:0042803 PMID:17487425 IPI UniProtKB:Q99PV5 F Class E basic helix-loop-helix protein 41 protein taxon:10090 20111216 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:1915050 Dgat2 enables GO:0042803 PMID:21680734 IPI UniProtKB:Q9DCV3 F Diacylglycerol O-acyltransferase 2 protein taxon:10090 20111130 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:1923615 Tbx18 enables GO:0042803 PMID:17584735 IPI UniProtKB:Q9EPZ6 F T-box transcription factor TBX18 protein taxon:10090 20191030 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:1859546 Syt10 enables GO:0042803 PMID:10531343 IDA F Synaptotagmin-10 protein taxon:10090 20110630 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:1859544 Syt6 enables GO:0042803 PMID:10531343 IDA F Synaptotagmin-6 protein taxon:10090 20110630 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:1316652 Prmt2 enables GO:0042803 GO_REF:0000024 ISS UniProtKB:P55345 F Protein arginine N-methyltransferase 2 protein taxon:10090 20110403 BHF-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:1351322 Mixl1 enables GO:0042803 PMID:22164283 IPI UniProtKB:Q9WUI0 F Homeobox protein MIXL1 protein taxon:10090 20121029 BHF-UCL `

gorule-0000061

Allowed gene product to term relations (gp2term)

• total: 3

messages

• WARNING - Violates GO Rule:GORULE:0000061: Found violation of: `Only certain gene product to term relations are allowed for a given GO term` but was repaired: RO:0002432 should be one of BFO:0000050. Repaired to BFO:0000050--`MGI MGI:109244 Sema4d is_active_in GO:0002116 PMID:22019888 IMP C Semaphorin-4D protein taxon:10090 20230823 BHF-UCL occurs_in(CL:0000062) `
• WARNING - Violates GO Rule:GORULE:0000061: Found violation of: `Only certain gene product to term relations are allowed for a given GO term` but was repaired: RO:0002432 should be one of BFO:0000050. Repaired to BFO:0000050--`MGI MGI:95410 Erbb2 is_active_in GO:0002116 PMID:22019888 IMP C Receptor tyrosine-protein kinase erbB-2 protein taxon:10090 20230823 BHF-UCL occurs_in(CL:0000062) `
• WARNING - Violates GO Rule:GORULE:0000061: Found violation of: `Only certain gene product to term relations are allowed for a given GO term` but was repaired: RO:0002432 should be one of BFO:0000050. Repaired to BFO:0000050--`MGI MGI:2154238 Plxnb1 is_active_in GO:0002116 PMID:22019888 IMP C Plexin-B1 protein taxon:10090 20230823 BHF-UCL occurs_in(CL:0000062) `